Over the last several years, major advances in genomics–specifically, the way diseases manifest and develop in the body at the genetic level–are improving our ability to target illness at each stage and improve the patient experience. As a result, we’re sometimes better able to predict which treatments could be most effective by taking into account patients’ individual differences in genetic make-up, environment and lifestyle. Perhaps the best example of this approach is CART-19, the investigational therapy we’re working on with the University of Pennsylvania. It is designed to hunt and destroy cancer cells, and has shown exciting potential for acute lymphoblastic leukemia (ALL).
Another promising area of investigation is CRISPR (clustered regularly interspaced short palindromic repeats). With this technology, we may be able to precisely delete, repair or replace the genes that cause currently untreatable diseases, such as cystic fibrosis.
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